Sepsis

Albumin administration improves survival in severe sepsis and septic shock – the ALBIOS study

(http://clinicaltrials.gov/ct2/show/NCT00707122)

In a presentation at the European Society for Intensive Medicine Congress in Lisbon in October 2012, Professor Luciano Gattinoni from the Ospedale Maggiore Policlinico of Milan reported the first findings from this important study on the use of 20% albumin in the resuscitation of patients with sepsis and septic shock. The study design is available on: http://www.negrisud.it/albios/materiale/2_ALBIOS_complete.ppt.

 

The full findings will be published in late 2013, but the important finding is a significant improvement in survival in patients given albumin compared to crystalloid solutions. (Table)

 

Mortality at Hospital Discharge

 

Albumin

Crystalloid

Non-Survivors

326

342

Total

908

907

Hear Professor Gattinoni discuss this study on http://www.esicm.org/news-article/icTV-video-ALBIOS-Trial-Albumin-Severe-Sepsis-Gattinoni

 

 

Albumin for volume replacement in severe sepsis. The ALBIOS trial. 2012, Lisbon. Gattinoni,L.